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KMID : 1001020140120030124
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Korean Journal of Urological Oncology
2014 Volume.12 No. 3 p.124 ~ p.131
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Predictive Factors for Maximal Size Reduction of Renal Target Lesion in Patients with Metastatic Renal Cell Carcinoma Receiving Targeted Therapies
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Kim Sung-Han
Cho In-Chang
Kim Sun-Ho
Joung Jae-Young
Seo Ho-Kyung
Lee Kang-Hyun
Yuk Heong-Dong
Chung Jin-Soo
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Abstract
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Purpose: To evaluate the renal target lesion response in metastatic renal cell carcinoma (mRCC) patients treated with targeted therapy (TT) and to determine predictive factors for maximal tumor size reduction.
Materials and Methods: We reviewed the clinical and radiographic data of 43 mRCC patients with 47 primary renal target legions (RTL) treated with at least two cycles of TT between 2007 and 2011. RTL response was evaluated using Response Evaluation Criteria Solid Tumors (RECIST) v.1.1. The significant predictive factors corresponding to the best response of RTL size reduction between the size reduction group (RG, n=36) and the non-reduction group (NRG, n=11) was statistically analyzed.
Results: During a median follow-up period of 7.4 months, median RTL size was 82mm and its mean change in size was -7.35mm. Multivariate analysis showed that body surface area (BSA) (p=0.016) and RTL size (p=0.024) were independently significant in shorter time to maximize size reduction. After classification of four RTL groups according to the combination of BSA of 1.62m2 and RTL size of 82mm, significant differences in time to maximal size reduction were observed (log rank, p=0.009).
Conclusions: BSA and RTL size were the best predictive factors for reduction of RTL size with time for maximal tumor response during TT.
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KEYWORD
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Renal cell carcinoma, Targeted therapy, Response, Size
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